Contamination of Commercial l -Leucine Preparations with Methionine and Cystine

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Contamination of Commercial L-leucine Preparations with Methionine and Cystine.

methods to remove methionine from L-leucine (Fox, Science 84:163, 1936; Bergmann and Stein, J. Biol. Chem. 129:609, 1939), I was surprised to find that certain current preparations of commercial L-leucine, supposedly of high quality, are heavily contaminated with methionine and also with cystine. In an examination of the requirements of a series of Bacillus subtilis mutants, the four types show...

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The Metabolism of Cystine and Methionine

Preformed protein, or its hydrolysis products, is one of the inevit.able needs of the more complexly organized animal body. The particular metabolic requirement for each individual amino acid yielded by protein is, therefore, a matter of outstanding importance. Although it has been clearly recognized for some 20 years that amino acids might well differ in their degrees of nutritional significan...

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Contaminants in commercial preparations of ‘purified’ small leucine-rich proteoglycans may distort mechanistic studies

The present study reports the perplexing results that came about because of seriously impure commercially available reagents. Commercial reagents and chemicals are routinely ordered by scientists and expected to have been rigorously assessed for their purity. Unfortunately, we found this assumption to be risky. Extensive work was carried out within our laboratory using commercially sourced prep...

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Methionine Requirement and Commercial Methionine Sources in Growing Pigs

Methionine is a limiting amino acid in commercial swine diets and commonly supplemented as dry DL-methionine (DL-Met, 99%) or as liquid DL-methionine hydroxy analogue-free acid (liquid MHA-FA, containing 88% of active substance). New and intriguing research has been published in poultry and swine as to what is the nutritional effectiveness of liquid MHA-FA relative to DLMet, and what are the re...

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Effect of hyperglycemia on in vitro tumor uptake of tritiated FDG, thymidine, L-methionine and L-leucine.

UNLABELLED We have previously demonstrated in vitro and in vivo that tumor uptake of FDG is markedly diminished by acute hyperglycemia. This in vitro study was designed to determine if tumor uptake of PET tracers (FDG, thymidine, L-methionine and L-leucine) is affected by acute or chronic hyperglycemia. METHODS Human ovarian adenocarcinoma (HTB 77 IP3) cells were grown in media containing 100...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1965

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.89.4.1162-1162.1965